Ball pythons aren't eating

I have 2 ball pythons. One regular and one blue eyed leucistic. Neither are eating. Have 50%-70% humidity all the time. I have a bunch of hiding places for them and pig water dishes and deep substrate. The bigger regular is in a 40 gallon and the smaller one is in a 25 gallon.

One of the weird things the regular is doing, is when I move my hand like a mouse next to the enclosure, she will strike at the glass like it's a prey item but will coward from a mouse.

The other one just completely ignores food. I've tried frozen and live. Mice and rats.

I'm worried about them starving to death honestly.

What could be causing this?