Moments in games where you just said "Oh no"?

As the title states, what're some moments in games where you just knew were going to have rough time, or that things were about to get dire?

Metroid Dred is already a pretty dire game. Samus is stuck in Raven Beak's giant facility, with hostile animals and 7 nigh-invincible robots trying to kill her. Then you get to Elun. Turns out, that footage of the X-Parasites on ZDR was real. And after a bit, these gummy bastards get released out into the rest of ZDR, and infect the entire planet within minutes. When that moment happened, I just went "Shit's fucked, time to blow up the planet."