Ignore Defense Items + Att or Dex?

So I was wondering whether Tshot (since it now ignores defense) or any other Defense-ignoring bow/item is better with more dex or att. My first stopping point was when considering the damage is the same in 0 def enemies and 100 def enemies, and if its better to make their average damage higher, or to land more shots (as to say, landing one/multiple extra shots account for landing a shot with higher damage). Can someone help me with this?